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ExCell(CB) CB055-2722 HRG1-β1, Human

ExCell(CB) CB055-2722 HRG1-β1, Human 50.0ug 上海有现货,数量500个

  • 商品编号:01.ExCell(CB).CB055-2722
  • 货号:01.ExCell(CB).CB055-2722
  • 品  牌:ExCell(CB)
  • 计量单位:
  • 所得积分:360
  • 市场价: ¥900.00
  • 销售价: ¥720.00
  • 节省:¥180.00
  • 广州仓库:无现货  上海仓库:有现货  北京仓库:无现货
    (库存情况仅供参考,请来电确认准确的现货情况)
  • 本商品仅供科研之用,不可用于临床
品牌: ExCell(CB)
货号:CB055-2722
规格:50.0μg
表达系统:E. coli
内毒素:< 0.2 EU/μg, determined by LAL method.
生物活性:ED50 < 1 ng/mL, measured by a cell proliferation assay using MCF-7 cells, corresponding to a specific activity of > 1× 106 units/mg.
保存条件:-80℃
保存时间:1年
应用:Growth/Differentiation
产品描述:Heregulin1-Beta1(HRG1-Beta1) is one of the isoforms encoded by Neuregulin (NRG) genes. NRGs are synthesized as large transmembrane precursor proteins, and the NRG family has 4 members and 26 isoforms. These isoforms provide large diversities, including different tissue distribution, variable potencies, and different biological functions. HRG1-β1 belongs to Type I HRG1, and is expressed in neural tissue, respiratory epithelia, and heart. In vivo, HRG1 binds and activates both ErbB3 and ErbB4, the transmembrane receptor tyrosine kinase, and is involved in the proliferation, differentiation, and survival of cells. Aberrantly produced HRG1 could be used in the constitute activation of the ErbB receptors; therefore, the upregulation of HRG1 contributes to the development of tumors, including breast cancer.
Recombinant human Heregulin1-Beta1(HRG1-Beta1) produced in E. coli is a single non-glycosylated polypeptide chain containing 66 amino acids. A fully biologically active molecule, rh HRG1-Beta1 has a molecular mass of 7.6 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at ExCell Bio.

 

 
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