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ExCell(CB) CB055-1411 Fractalkine/CX3CL1, Human

ExCell(CB) CB055-1411 Fractalkine/CX3CL1, Human 5.0ug 上海有现货,数量500个

  • 商品编号:01.ExCell(CB).CB055-1411
  • 货号:01.ExCell(CB).CB055-1411
  • 品  牌:ExCell(CB)
  • 计量单位:
  • 市场价: ¥600.00
  • 销售价: ¥600.00
  • 广州仓库:无现货  上海仓库:有现货  北京仓库:无现货
    (库存情况仅供参考,请来电确认准确的现货情况)
  • 本商品仅供科研之用,不可用于临床
品牌:ExCell(CB)
货号:CB055-1411
规格:5.0μg
表达系统:CHO
内毒素:< 0.2 EU/μg, determined by LAL method.
生物活性:The EC50 value of Human Fractalkine/CX3CL1 on Ca2+ mobilization assay in CHO-K1/Gα15/hCX3CR1 cells (human Gα15 and hCX3CR1 stably expressed in CHO-K1 cells) is less than 1.5 μg/ml.
保存条件:-80℃
保存时间:1年
应用:Growth/Differentiation
产品描述:Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a known member of the CX3C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice). The polypeptide structure of CXC3L1 differs from the typical structure of other chemokines. For example, the spacing of the characteristic N-terminal cysteines is different; there are three amino acids separating the initial pair of cysteines in CX3CL1, while there are none in CC chemokines and only one in CXC chemokines. CX3CL1 is produced as a long protein (with 373-amino acid in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk allows it to bind to the surface of certain cells. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound chemokine promotes strong adhesion of leukocytes to activated endothelial cells, where it is primarily expressed. CX3CL1 can signal through the chemokine receptor CX3CR1.
Recombinant Human Fractalkine/CX3CL1 produced in CHO cells is a polypeptide chain containing 315 amino acids. A fully biologically active molecule, rhFractalkine/CX3CL1 has a molecular mass of 50-75 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at ExCell Bio.
 
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