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ExCell(CB) CB055-0281 人骨形态发生蛋白-2 (BMP-2) 10.0μg 

  • 商品编号:01.EXCELL(CB).CB055-0281
  • 货号:01.EXCELL(CB).CB055-0281
  • 品  牌:ExCell(CB)
  • 所得积分:364
  • 市场价: ¥910.71
  • 销售价: ¥728.57
  • 节省:¥182.14
  • 广州仓库:无现货  上海仓库:有现货  北京仓库:无现货
    (库存情况仅供参考,请来电确认准确的现货情况)
  • 本商品仅供科研之用,不可用于临床

Bone Morphogenetic Protein-2 (BMP-2), Human 

Catalog #
CB055-0281
Species
Human
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Endotoxin Level
< 1 EU/μg, determined by LAL method.
Biological Activity
ED50 < 1 μg/ml, measured by alkaline phosphatase induction assay using C2C12 cells.
Source
E. coli
Molecular Weight
26 kDa, observed by non-reducing SDS-PAGE
Description
Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and belongs to the transforming growth factor-beta (TGF-beta) superfamily. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecule (Met1-Arg396, with a signal peptide from Met1 to Gly23), propeptide (Leu24-Arg282) of which is cleaved by PCSK5 (Proprotein Convertase Subtilisin/Kexin type 5). The active form consists of a dimer of two identical proteins which are linked by a disulfide bond at Cys360. It plays an important role in the development of bone and cartilage, cardiac cell differentiation and epithelial to mesenchymal transition. It is also involved in the hedgehog pathway, TGF-beta signaling pathway, and in cytokine-cytokine receptor interaction. Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 115 amino acids. A fully biologically active molecule, rhBMP-2 has a molecular mass of 26 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques
Formulation
Lyophilized after extensive dialysis against 50 mM acetic acid
Reconstitution
Reconstituted in 20 mM AcOH or 5 mM HCl. The solubility should be at 100 μg/ml.
Storage
Lyophilized recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhBMP-2 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

 
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